Moby-Dick is the second show in a trilogy of Wattis Institute exhibitions that are based on canonical American novels. The first, The Wizard of Oz, was presented in fall 2008; the third will be The Adventures of Huckleberry Finn, in fall 2010. All three stories have major themes related to exploration and (self-)discovery, and the corresponding exhibitions function as metaphorical journeys through which the audience experiences various notions of America's reality, both contemporary and historic. Established and emerging contemporary artists from around the world are invited to address the key themes of the books and the historical moments in which they were written. Many of the artists create new commissions specifically for the shows.

This investigation of America and its realities through the lens of literature by means of artworks, artifacts, and historical documents is unique to the Wattis Institute. Moby-Dick will encompass a wide range of works, including sculpture, film, video, drawing, and photography.